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Esomeprazole delayed-release oral capsule dosage: A detailed guide

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Doctors prescribe esomeprazole delayed-release oral capsule for conditions caused by too much acid in the stomach. You take it by mouth once per day.
Medically reviewed by Paul Hetrick, PharmD
Updated on

This article describes esomeprazole delayed-release oral capsule’s dosages and strengths and gives details on how to take it. You’ll also find information on cost savings and coupon options for esomeprazole. If you want to know more about esomeprazole delayed-release oral capsule, see this overview article. It covers details about the drug’s uses and side effects, and more.

Esomeprazole magnesium delayed-release oral capsule is a generic version of the brand-name drug Nexium. “Delayed release” means the drug is slowly released in your body after you swallow it.

Esomeprazole also comes in a suspension form taken by mouth (esomeprazole magnesium) and an injectable form (esomeprazole sodium), but those forms aren’t described in this article. To learn more about those forms, talk with your doctor.

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Form and strengths of esomeprazole

Esomeprazole delayed-release oral capsule comes as follows:

  • Form: oral delayed-release capsule, which you’ll take by swallowing
  • Strengths: 20 milligrams (mg), 40 mg

Dosage of esomeprazole

This article describes the recommended dosages for esomeprazole delayed-release oral capsule. The drugmaker provides these dosages.

If your doctor prescribes this medication, you should follow the dosage they prescribe. Your doctor will determine the dosage that best meets your needs. Do not change your dosage of esomeprazole delayed-release oral capsule without your doctor’s recommendation.

Usual recommended dosages of esomeprazole in adults

Usually, doctors start by prescribing a low dosage of esomeprazole delayed-release oral capsule. Then, they’ll adjust it over time until the right dosage is reached. Ultimately, your doctor will prescribe the smallest dosage of esomeprazole delayed-release oral capsule that gives the desired outcome.

Recommended dosages for esomeprazole delayed-release oral capsule in adults are shown in the table below.

Condition/purposeRecommended doseFrequencyLength of treatment
erosive esophagitis (treatment)20 mg or 40 mgonce daily4 to 8 weeks (with an additional 4 to 8 weeks as needed)
erosive esophagitis (healing maintenance)20 mgonce dailyup to 6 months
gastroesophageal reflux disease (GERD) symptoms20 mgonce daily4 to 8 weeks
prevent stomach ulcers caused by nonsteroidal anti-inflammatory drugs (NSAIDs)20 to 40 mgonce dailyup to 6 months
Helicobacter pylori (H. pylori) infection40 mgonce daily10 days
hypersecretory conditions, including Zollinger-Ellison syndromestarting dose: 40 mg

dose can be adjusted to meet patient needs

maximum dose over 24 hours: 240 mg
twice dailyas long as needed

H. pylori is a type of bacteria. To help get rid of H. pylori infection, doctors prescribe esomeprazole delayed-release oral capsule together with other medications.

Hypersecretory conditions are conditions that cause too much acid to be made in the stomach.

Dosages of esomeprazole in children

Esomeprazole delayed-release capsule is also approved for use in children ages 12 years and older.

ConditionRecommended doseFrequencyLength of treatment
erosive esophagitis (treatment)20 mg or 40 mgonce daily4 to 8 weeks
GERD symptoms20 mgonce daily4 weeks

Dosage adjustments for esomeprazole

Your doctor will prescribe a dosage of esomeprazole delayed-release oral capsule based on several factors. These include:

  • the specific condition being treated and how severe it is
  • your age
  • other health conditions you may have, such as liver problems
  • taking other medications that may interact with esomeprazole delayed-release oral capsule

Missed dose of esomeprazole

Talk with your doctor or pharmacist right away if you realize you forgot to take a dose of esomeprazole delayed-release oral capsule. They may advise you to take the missed dose. Or they may advise you to skip it and take your next dose as scheduled.

For tips on how to plan your doses of esomeprazole delayed-release oral capsule and avoid missing a dose, read this article. You could also try:

  • downloading a reminder app on your phone
  • setting an alarm
  • putting a note where you’ll see it, such as on your calendar, bathroom mirror, or bedside table

Frequently asked questions

Below are answers to some commonly asked questions about esomeprazole delayed-release oral capsule and its dosage.

When is the best time of day to take esomeprazole?

There’s no best time of day to take esomeprazole delayed-release oral capsule. But it’s best to take the medication around the same time each day. This helps to keep a steady level of the drug in your body at all times. It’s recommended that you take esomeprazole delayed-release oral capsule at least 1 hour before a meal.

If you have more questions about the timing of taking your esomeprazole dose, talk with your doctor or pharmacist.

Should I take my dose of esomeprazole before or after food?

Take esomeprazole delayed-release oral capsule at least 1 hour before a meal.

Is esomeprazole taken long term?

No, doctors don’t typically prescribe esomeprazole delayed-release oral capsule as a long-term treatment. Instead, it’s usually recommended for short-term use.

If you have questions about how long you should take esomeprazole delayed-release oral capsule, talk with your doctor.

How esomeprazole is taken

You’ll swallow esomeprazole delayed-release oral capsule once per day. Esomeprazole delayed-release oral capsule should be swallowed whole with plenty of liquid. Do not chew or crush the capsule. If you can’t swallow it, you can open the capsule and mix the contents with applesauce.

Your doctor may advise that you take this medication around the same time each day. This helps keep a consistent amount of the drug in your body. And that can help the drug work more effectively.

If it’s hard for you to swallow capsules, view this article. It provides suggestions on how to swallow medications that come in pill form.

Also, be sure to talk with your doctor or pharmacist if you’re having difficulty taking your medication. They can offer recommendations about taking it.

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Overdose of esomeprazole

It’s important that you do not take more esomeprazole delayed-release oral capsule than your doctor prescribes. Doing so can lead to harmful effects.

Symptoms of esomeprazole overdose

Symptoms of an overdose can include:

What to do if you take too much esomeprazole

If you think you’ve taken too much esomeprazole, call your doctor or pharmacist right away. Or you could call 800-222-1222 to speak with someone at America’s Poison Centers. You can also use its online resource. If you have severe symptoms, call 911 or a local emergency number immediately. You can also go to the closest emergency room.

What to ask your doctor

This article describes the usual recommended dosages for esomeprazole delayed-release oral capsule. If your doctor prescribes this medication, they’ll determine the dosage that’s best for you.

Do not change your dosage of esomeprazole delayed-release oral capsule without your doctor’s recommendation. You should take esomeprazole delayed-release oral capsule exactly as your doctor prescribes it. Let your doctor know if you have concerns or questions about your treatment plan.

Here’s a list of some possible questions you may want to ask your doctor:

  • What determines whether my dosage of esomeprazole delayed-release capsule is right for my condition?
  • Will my dosage of esomeprazole delayed-release oral capsule change if I’m taking other medications with it?
  • Will I experience more side effects with a higher dose of esomeprazole delayed-release oral capsule?

Disclaimer: Optum Perks has made every effort to make certain that all information is factually correct, comprehensive, and up to date. However, this article should not be used as a substitute for the knowledge and expertise of a licensed healthcare professional. You should always consult your doctor or another healthcare professional before taking any medication. The drug information contained herein is subject to change and is not intended to cover all possible uses, directions, precautions, warnings, drug interactions, allergic reactions, or adverse effects. The absence of warnings or other information for a given drug does not indicate that the drug or drug combination is safe, effective, or appropriate for all patients or all specific uses.

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